Which statement best describes the presentation of myasthenia gravis?

• A. Seizures
• B. Tremor at rest
• C. Memory loss
• D. Fatigable muscle weakness that worsens with use

Answer: (D)

Myasthenia gravis is a disorder of impaired neuromuscular transmission due to autoimmune antibodies against acetylcholine receptors at the motor end plate. Because transmission fails more quickly with use, strength wanes after sustained activity and improves with rest. Clinically, this often shows up as ocular involvement—ptosis and diplopia—along with weakness that worsens with use and may involve bulbar or proximal limb muscles. Sensation and reflexes are typically normal. This picture contrasts with symptoms like seizures, tremor at rest, or memory loss, which point to other neurologic processes. So the best description of MG presentation is fatigable muscle weakness that worsens with use.